Deadline: 3 Dec. 2012
Salary and appointment termsThe salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.
Further information
A PhD position is available at the Center for Microbial Biotechnology (CMB), aiming at designing and utilizing fungal cell factories that can produce water-soluble pigments in bioreactors.
Center for Microbial Biotechnology (CMB) has an in-depth knowledge on phenotypic characterisation of fungal species with backbone knowledge on metabolite production by fungi growing on different substrates and under different abiotic conditions. This includes the ability to express pigments in many different colours. Recent projects have generated a substantial body of knowledge on how the pigment production is influenced by different physiological growth conditions in a lab-scale production environment, and the present project should examine an array of growth media with different nutrients, pH, water activities and other chemical stimuli. The present knowledge is mainly related to wild-type strains of several common filamentous fungi that can produce water-soluble pigments, representing all colours of the rainbow. Many of these pigments are polyketides and CMB has an extensive knowledge on the genetic set-up of polyketide gene clusters, possible transcription factors and how to manipulate these, as well as on the pigment chemistry.
The present project will aim at extending knowledge on pigment formation in filamentous fungi ultimately resulting in scale-up from solid and shake flask cultures to bioreactors aiming at a yield in an industrial scale.
Qualifications
Center for Microbial Biotechnology (CMB) has an in-depth knowledge on phenotypic characterisation of fungal species with backbone knowledge on metabolite production by fungi growing on different substrates and under different abiotic conditions. This includes the ability to express pigments in many different colours. Recent projects have generated a substantial body of knowledge on how the pigment production is influenced by different physiological growth conditions in a lab-scale production environment, and the present project should examine an array of growth media with different nutrients, pH, water activities and other chemical stimuli. The present knowledge is mainly related to wild-type strains of several common filamentous fungi that can produce water-soluble pigments, representing all colours of the rainbow. Many of these pigments are polyketides and CMB has an extensive knowledge on the genetic set-up of polyketide gene clusters, possible transcription factors and how to manipulate these, as well as on the pigment chemistry.
The present project will aim at extending knowledge on pigment formation in filamentous fungi ultimately resulting in scale-up from solid and shake flask cultures to bioreactors aiming at a yield in an industrial scale.
Qualifications
- MSc. Degree in Biotechnology or Life Sciences (e.g. microbiology, fermentation technology, biochemistry, molecular biology)
- Practical experience working with fungi
- Practical experience with submerged cultivation of micro-organisms is preferably but not a requirement
- General knowledge about molecular biology tools for fungi
- The ability to collaborate as well as communicate, promote and utilize research results
- Good communication skills in English, both written and spoken.
Salary and appointment termsThe salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.
Further information
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