Deadline: 31 Jan. 2014
Description
Eye research has often blazed a trail for other disciplines to follow, giving a lead in neuroscience, genetics, gene- and stem-cell therapies and other important areas of medical research. In recent years, geneticists have made many remarkable discoveries of relevance both to normal human vision and the development of inherited retinal pathology. However the genes and mutations implicated account for only a proportion of cases of inherited retinal disorders (RD), and recent discoveries hint at new classes of mutations which are either largely undetected or the significance of which is missed by conventional genetics. For those genes implicated there often remains a black box between mutations and disease; how do defects in a given protein manifest symptoms in the eye and what underlies the huge variation in symptoms, severity and response to treatment? EyeTN addresses these knowledge gaps with cutting edge techniques, including transcriptomics, whole genome and single target RNAi, the development of animal and cell-based disease models, stem cell biology, bioinformatics and hands on experience of pharmaceutical research with direct translational targets.
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