Deadline: 31 Jan. 2014
Project: Bioinformatics and genomic data integration in urinary bladder cancer: crossing borders.
Urinary bladder cancer (UBC) is the ninth most common tumor worldwide. Our research group aims to contribute to improved treatment and prognosis for UBC patients via elucidation of its genetic background. Improved genotyping technologies have allowed for an in-depth interrogation of variation in the germline and tumor genome in large study populations. Also, efforts like The Cancer Genome Atlas (TCGA) project have led to a tremendous wealth of data on somatic mutations and gene expression in bladder tumor tissue. One of the biggest challenges in genetic research nowadays is to use and integrate all these data. In this project, we aim to optimally exploit and integrate germline genomic data from Dutch and Icelandic UBC populations and data on gene expression and somatic mutations in the quest for (rare) germline variants, genes and pathways for bladder cancer.
The PhD student on this project will be responsible for an integrative analysis of germline genomic and other -omic data in bladder cancer. He or she will evaluate existing data integration techniques and tailor these for application to the UBC data at hand. The results will be disseminated via presentations and articles in peer-reviewed journals.
The PhD student on this project will be responsible for an integrative analysis of germline genomic and other -omic data in bladder cancer. He or she will evaluate existing data integration techniques and tailor these for application to the UBC data at hand. The results will be disseminated via presentations and articles in peer-reviewed journals.
More information about this vacancy can be obtained from Dr. Sita Vermeulen, Department for Health Evidence & Human Genetics, Radboud university medical center, +31 24 361 31 27 orSita.Vermeulen@radboudumc.nl.
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