Netherlands: The Netherlands Cancer Institute is looking for a PhD student

Deadline: 30 April 2013

Job description

Project: The project, which is funded by the Dutch Cancer Society, aims to explore DDT as a drug-target for chemosensitization. As effective DDT strongly depends on site-specific PCNA-ubiquitination, a DDT blockade will increase platinum drug efficacy without increasing neuro- and nephrotoxicity. To reveal the chemosensitizing potential of a DDT blockade, PCNA-ubiquitination will be blocked at the genetic and biochemical level. In addition, the contribution of error-prone PCNA-Ub dependent DDT in tumor development and progression will be determined in our PCNAK164R mutant mice.
Project: The project, which is funded by the Dutch Cancer Society, aims to explore DDT as a drug-target for chemosensitization. As effective DDT strongly depends on site-specific PCNA-ubiquitination, a DDT blockade will increase platinum drug efficacy without increasing neuro- and nephrotoxicity. To reveal the chemosensitizing potential of a DDT blockade, PCNA-ubiquitination will be blocked at the genetic and biochemical level. In addition, the contribution of error-prone PCNA-Ub dependent DDT in tumor development and progression will be determined in our PCNAK164R mutant mice.
RequirementsConditions of employmentApart from being a specialized institute and hospital with good working conditions and an excellent atmosphere, the NKI has also been listed in the top 10 of ‘Best Employers’ in 2011. The NKI ranked over the last years among the top 10 as the best place to work as a postdoc outside the USA (the Scientist). Amsterdam is an attractive place to live and work with many cultural amenities. The institute is located in the city and within 20 minutes from Schiphol airport.
Apart from being a specialized institute and hospital with good working conditions and an excellent atmosphere, the NKI has also been listed in the top 10 of ‘Best Employers’ in 2011. The NKI ranked over the last years among the top 10 as the best place to work as a postdoc outside the USA (the Scientist). Amsterdam is an attractive place to live and work with many cultural amenities. The institute is located in the city and within 20 minutes from Schiphol airport.
Organisation

The Netherlands Cancer Institute (NKI-AVL)

The Netherlands Cancer Institute, the research laboratory of the Antoni van Leeuwenhoek hospital (NKI-AVL), is a world-class institute for cancer research and cancer care based in Amsterdam. Its mission is to combat cancer through excellence in patient care and scientific research. In comparison with large universities, NKI-AVL is a relatively small and highly focussed organisation. Within a flat management structure, over 2,100 dedicated scientists, physicians and staff members work in a specialised clinical care unit with 180 beds (AVL) and a closely associated research institute (NKI). Together they treat close to 30,000 patients, produce over 400 scientific publications and support the granting of 30 PhD degrees per year.

Please contact Dr. Heinz Jacobs, tel. + (31) 20 512 2065, e-mail:h.jacobs@nki.nl and check our website www.nki.nl.