Deadline: 1st Nov. 2012
University of Bath -Department of Electronic & Electrical Engineering, Department of Chemistry
Early Stage Researcher 36-month position leading to a PhD.
In this project, electrochemical techniques will be optimised for the detection of prostate cancer biomarkers using DNA-based approaches, including DNA aptamers, PNA, peptide-DNA interactions and novel synthetic receptors. We will explore the immobilisation of DNA PNA and peptide aptamers along with new types of synthetic receptors to investigate target binding. We will test the novel arrays in the electrochemical sensing (potentiometric and impedimetric) of PCa biomarkers and assess the performance in purified and spiked samples; test the conjugation of ferrocene derivatives to the recognition element (antibody, PNA or DNA) to investigate changes in signal.
PROSENSE is a coordinated research training network involving academia, industry and hospitals, bringing together training across disciplines and across sectors, complemented by researcher career development tools. A full programme of cross-disciplinary and cross-sectoral secondments, training and events will enable PROSENSE to promote interaction, knowledge exchange and collaboration in the multidisciplinary field of biosensor design with the aim of developing improved devices for prostate cancer diagnosis, prognosis and treatments. It will increase understanding of clinical relevance of prostate cancer biomarkers and elucidate how the concurrent analysis of biomarkers can inform therapy; improve sensitivity, selectivity, robustness and speed of biosensing technologies for the simultaneous screening of biomarkers; develop lab-on-a-chip devices requiring minute amounts of clinical samples and increase likelihood of viable fit-for-purpose prostate cancer biosensing products.
Candidate should have a good honours degree in the fields of Chemistry, Biochemistry, Biomedical Engineering, Electrical Engineering, Physics or a related area.
Funding Details:
This fellowship will provide an attractive salary of circa £30k per year as well as a mobility allowance.
This fellowship will provide an attractive salary of circa £30k per year as well as a mobility allowance.
Length of Award: 3 years
Eligibility:
Strict eligibility and mobility criteria apply to this Marie Curie Fellowship: at the time of recruitment you must have less than 4 years since the degree that enables you to embark into a PhD; you must not have already a PhD; you can be of any nationality but cannot have spent more than 12 months in the last 3 years in the United Kingdom.
Strict eligibility and mobility criteria apply to this Marie Curie Fellowship: at the time of recruitment you must have less than 4 years since the degree that enables you to embark into a PhD; you must not have already a PhD; you can be of any nationality but cannot have spent more than 12 months in the last 3 years in the United Kingdom.
Application Details:
Details on the application process can be found on http://www.prosense-itn.eu.
Details on the application process can be found on http://www.prosense-itn.eu.
Please contact Dr Pedro Estrela (email p.estrela@bath.ac.uk) for further information.
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